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KMID : 0364920120370010050
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Journal of Radiation Protection and Research
2012 Volume.37 No. 1 p.50 ~ p.55
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Evaluation of the Photoprotective Effect of Dongchongxiacao (Paecilomyces japonica) Extract against Ultraviolet Radiation-induced Skin Wrinkling and Cancer
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Lee Hae-June
Moon Chang-Jong
Kim Jong-Choon
Jung U-hee
Jo Sung-Kee
Jang Jong-Sik
Kim Seong-Ho
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Abstract
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To evaluate the ability of Dongchongxiacao (Paecilomyces japonica) extract (PJE) to protect the skin from photodamage, the gross and microscopic changes in the skin of hairless mice and PJE-treated mice exposed chronically to ultraviolet (UV) were examined. The skin of the UV-irradiated mice showed characteristic signs of photoaging, such as deep wrinkles across the back. PJE-treated mice showed a significantly decreased wrinkling score. By the 22nd week, 88.9% (i.p. with saline) or 44.4% (topical administration with cream base) of the UV-irradiated mice developed at least one tumor. PJE delayed tumor onset significantly. PJE (i.p.) was also effective in reducing the occurrence of UV radiation-induced skin tumors and reduced the number of tumors per mouse. After 22 weeks of treatment, 80.0% (i.p.) and 75.0% (topical) of the mice treated with PJE were tumor-free. Tumor multiplicity was reduced by 96.2% (i.p.) in the PJE treated groups. It is noted that skin that is chronically exposed to UV is subject to photoaging and photocarcinogenesis and regular use of PJE would prevent these photodamaging effects of UV.
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KEYWORD
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Dongchongxiacao (Paecilomyces japonica), Ultraviolet, Skin wrinkling, Photocarcinogenesis
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